id: Pfam:PF02410
pfam_id: PF02410
name: Ribosomal silencing factor during starvation
short_name: RsfS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02410
counters:
  proteins: 21229
  matches: 21269
  proteomes: 20133
  taxa: 31990
  structures: 56
  alphafold_models: 14690
  domain_architectures: 103
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
description: This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea.
  Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does
  this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing
  factor (RsfS) by blocking the joining of the ribosomal subunits [[cite:PUB00064845]]. This family is
  structurally homologous to nucleotidyltransferases.