id: Pfam:PF02415
pfam_id: PF02415
name: Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat
short_name: Chlam_PMP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02415
counters:
  proteins: 2631
  matches: 5667
  proteomes: 838
  taxa: 2170
  structures: 0
  alphafold_models: 1511
  domain_architectures: 557
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003368
description: This family contains several Chlamydia polymorphic membrane proteins. Chlamydia pneumoniae
  is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and
  lower respiratory tract. Common for the Pmps are the tetrapeptide GGA(I/V/L) motif repeated several
  times in the N-terminal part. The C-terminal half is characterised by conserved tryptophans and a carboxy-terminal
  phenylalanine. A signal peptide leader sequence is predicted in 20 C. pneumoniae Pmps, which indicates
  an outer membrane localisation. Pmp10 and Pmp11 contain a signal peptidase II cleavage site suggesting
  lipid modification. The C. pneumoniae pmp genes represent 17.5% of the chlamydia-specific coding capacity
  and they are all transcribed during chlamydial growth but the function of Pmps remains unknown [[cite:PUB00015051]].
  This family shows some similarity to [pfam:PF05594] and hence is likely to also form a beta-helical
  structure (personal obs:C Yeats).