id: Pfam:PF02520
pfam_id: PF02520
name: SXP/RAL-2 family protein Ani s 5-like, metal-binding domain
short_name: ANIS5_cation-bd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02520
counters:
  proteins: 2048
  matches: 2126
  proteomes: 94
  taxa: 232
  structures: 1
  alphafold_models: 1927
  domain_architectures: 50
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003677
description: 'This domain is found in proteins from nematodes, including SXP/RAL-2 family protein Ani
  s 5 (ANIS5) from Anisakis simplex, and comprises two conserved motifs: SXP1 and SXP2 [[cite:PUB00097764]].
  Although the function of this domain is not clear, structural information from ANIS5 revealed an alpha
  helical arrangement with a Calmodulin-like fold. Functional studies indicates that ANIS5 can bind magnesium
  and calcium, suggesting that this domain plays a role in cation binding [[cite:PUB00097763]]. These
  proteins are interesting targets to develop control strategies against the diseases caused by parasites.'