id: Pfam:PF02583
pfam_id: PF02583
name: Metal-sensitive transcriptional repressor
short_name: Trns_repr_metal
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02583
counters:
  proteins: 19403
  matches: 19412
  proteomes: 10791
  taxa: 15418
  structures: 12
  alphafold_models: 12146
  domain_architectures: 15
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003735
description: This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members
  of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In
  the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound
  to metal ions they are unable to bind DNA, leading to transcriptional derepression [[cite:PUB00041403],[cite:PUB00057455],[cite:PUB00057456],[cite:PUB00057457],[cite:PUB00035608]].