id: Pfam:PF02586
pfam_id: PF02586
name: SOS response associated peptidase (SRAP)
short_name: SRAP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02586
counters:
  proteins: 20212
  matches: 20441
  proteomes: 14674
  taxa: 23969
  structures: 19
  alphafold_models: 13289
  domain_architectures: 96
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003738
description: The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse
  repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member
  of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine,
  5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral
  aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might
  help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species
  as part of the DNA demethylation pathway downstream of the TET enzymes.