id: Pfam:PF02591
pfam_id: PF02591
name: C4-type zinc ribbon domain
short_name: Zn_ribbon_9
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02591
counters:
  proteins: 6047
  matches: 6047
  proteomes: 6025
  taxa: 8321
  structures: 4
  alphafold_models: 3806
  domain_architectures: 9
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003743
description: Zn-ribbon_9 is a Zn-ribbon domain rich in aromatic and positively charged amino acid residues.
  This C-terminal Zn-ribbon domain consists of two beta-strands acting as a scaffold for the two Zn knuckles.
  Both pairs of cysteines making up the two Zn knuckles are situated at highly conserved sharp beta-turns,
  an arrangement that facilitates the tetrahedral coordination of the divalent Zn ion. The two Zn-knuckle
  cysteine motifs are separated by 20 residues, 9 of which form an alpha-helix (helix 4) [[cite:PUB00075417]].Structural
  modelling suggests this domain may bind nucleic acids [[cite:PUB00070793]]. The domain appears to bind
  flaA-mRNA, thus contributing to flagellum formation and motility [[cite:PUB00075417]].