id: Pfam:PF02593
pfam_id: PF02593
name: Domain of unknown function
short_name: DUF166
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02593
counters:
  proteins: 267
  matches: 268
  proteomes: 149
  taxa: 354
  structures: 0
  alphafold_models: 241
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003745
description: This family catalyses the synthesis of thymidine monophosphate (dTMP) from deoxyuridine monophosphate
  (dUMP). The physiological co-substrate has not yet been identified. Previous designation of this family
  as being thymidylate synthase from one paper, [cite:PUB00075419], has been shown to be erroneous [[cite:PUB00057368]].
  The proteins are uncharacterised.