id: Pfam:PF02597
pfam_id: PF02597
name: ThiS family
short_name: ThiS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02597
counters:
  proteins: 36990
  matches: 36990
  proteomes: 17893
  taxa: 28116
  structures: 39
  alphafold_models: 24446
  domain_architectures: 112
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003749
description: ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer [swissprot:O32583]. ThiS
  is coded in the thiCEFSGH operon in E. coli. This family of proteins have two conserved Glycines at
  the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred
  from ThiI to ThiS in a reaction catalysed by IscS [[cite:PUB00007564]]. MoaD, [swissprot:P30748] a protein
  involved sulphur transfer in molybdopterin synthesis, is about the same length and shows limited sequence
  similarity to ThiS. Both have the conserved GG at the COOH end.