id: Pfam:PF02604
pfam_id: PF02604
name: Antitoxin Phd_YefM, type II toxin-antitoxin system
short_name: PhdYeFM_antitox
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02604
counters:
  proteins: 22715
  matches: 22715
  proteomes: 9546
  taxa: 14306
  structures: 24
  alphafold_models: 14574
  domain_architectures: 33
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR006442
description: Members of this family act as antitoxins in type II toxin-antitoxin systems [[cite:PUB00015218]].
  When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression
  of operons containing genes encoding the toxin and the antitoxin [[cite:PUB00054755]]. This domain complexes
  with Txe toxins containing [pfam:PF06769], Fic/DOC toxins containing [pfam:PF02661] and YafO toxins
  containing [pfam:PF13957].