id: Pfam:PF02617
pfam_id: PF02617
name: ATP-dependent Clp protease adaptor protein ClpS
short_name: ClpS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02617
counters:
  proteins: 19694
  matches: 19697
  proteomes: 15812
  taxa: 25224
  structures: 39
  alphafold_models: 10649
  domain_architectures: 120
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003769
description: In the bacterial cytosol, ATP-dependent protein degradation is performed by several different
  chaperone-protease pairs, including ClpAP. ClpS directly influences the ClpAP machine by binding to
  the N-terminal domain of the chaperone ClpA. The degradation of ClpAP substrates, both SsrA-tagged proteins
  and ClpA itself, is specifically inhibited by ClpS. ClpS modifies ClpA substrate specificity, potentially
  redirecting degradation by ClpAP toward aggregated proteins [[cite:PUB00013965]].