id: Pfam:PF02621
pfam_id: PF02621
name: Menaquinone biosynthesis
short_name: VitK2_biosynth
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02621
counters:
  proteins: 6058
  matches: 6185
  proteomes: 3141
  taxa: 4752
  structures: 13
  alphafold_models: 3768
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003773
description: This family includes two enzymes which are involved in menaquinone biosynthesis. One which
  catalyses the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate, and one
  which may be involved in the conversion of chorismate to futalosine [[cite:PUB00045374]]. These enzymes
  comprise two domains with alpha/beta structures, a large domain and a small domain. A pocket between
  the two domains may form the active site, a conserved histidine located within this pocket could be
  the catalytic base [[cite:PUB00057460]].