id: Pfam:PF02623
pfam_id: PF02623
name: FliW protein
short_name: FliW
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02623
counters:
  proteins: 3298
  matches: 3305
  proteomes: 3142
  taxa: 5053
  structures: 4
  alphafold_models: 2217
  domain_architectures: 8
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003775
description: 'The protein BSU35380 from Bacillus subtilis (renamed FliW) was characterised as being a
  flagellar assembly factor. Experimental characterisation was also carried out in Treponema pallidum
  (TP0658). In Campylobacter jejuni, Cj1075 has been shown to be involved in motility and flagellin biosynthesis.
  The two paralogues in Helicobacter pylori (HP1154 and HP1377) were found to be able to bind to flagellin.
  FliW proteins are involved in flagellar assembly [[cite:PUB00067598]]. FliW is part of a three-part
  feedback loop: in Bacillus subtilis FliW inhibits CsrA (an RNA-binding protein) which inhibits FliC
  translation; hence FliW is required for FliC (flagellin) production [[cite:PUB00067599]].'