id: Pfam:PF02626
pfam_id: PF02626
name: Carboxyltransferase domain, subdomain A and B
short_name: CT_A_B
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02626
counters:
  proteins: 16267
  matches: 16396
  proteomes: 11554
  taxa: 16297
  structures: 8
  alphafold_models: 9634
  domain_architectures: 95
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003778
description: Urea carboxylase (UC) catalyses a two-step, ATP- and biotin-dependent carboxylation reaction
  of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier
  protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain
  covers the A and B subdomains of the CT domain. This domain covers the whole length of KipA (kinase
  A) from Bacillus subtilis [[cite:PUB00064884]]. It can also be found in S. cerevisiae urea amidolyase
  Dur1,2, which is a multifunctional biotin-dependent enzyme with domains for urea carboxylase and allophanate
  (urea carboxylate) hydrolase activity[[cite:PUB00076467]].