id: Pfam:PF02643
pfam_id: PF02643
name: Uncharacterized ACR, COG1430
short_name: DUF192
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02643
counters:
  proteins: 8199
  matches: 8203
  proteomes: 7198
  taxa: 10914
  structures: 2
  alphafold_models: 5508
  domain_architectures: 19
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003795
description: Two structures have been solved for members of this large (>500 members) family of bacterial
  proteins present mostly in environmental bacteria and metagenomes (distant homologues are also present
  in several Plasmodium species). TOPSAN analysis for pdb:3pjy shows that there is much similarity with
  the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homologue of Thermotoga
  maritima TM1668, UniProt:Q9X1Z6., The homologue in Caulobacter crescentus (CC1388), UniProt:Q9A8G6,
  is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context
  of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in
  extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase
  and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823)
  protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t,
  3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are
  involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface
  of 3m7a (http://www.topsan.org/Proteins/JCSG/).