id: Pfam:PF02649
pfam_id: PF02649
name: Type I GTP cyclohydrolase folE2
short_name: GCHY-1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02649
counters:
  proteins: 4512
  matches: 4514
  proteomes: 4215
  taxa: 6631
  structures: 7
  alphafold_models: 3145
  domain_architectures: 9
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003801
description: This is a family of prokaryotic proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase
  I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi,
  and plants, and encoded in Escherichia coli by the folE gene; it is also the first enzyme of the biopterin
  (BH4) pathway in Homo sapiens[[cite:PUB00051207]]. The invariate, highly conserved glutamate residue
  at position 216 in [swissprot:Q5F9K6] is likely to be the substrate ligand and the metal ligand is likely
  to be the cysteine at position 147. The enzyme is Zinc 2+ dependent [[cite:PUB00057465]].