id: Pfam:PF02659
pfam_id: PF02659
name: Putative manganese efflux pump
short_name: Mntp
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02659
counters:
  proteins: 6974
  matches: 8099
  proteomes: 4717
  taxa: 7605
  structures: 0
  alphafold_models: 4558
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003810
description: MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains.
  It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity
  and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient
  for organisms from bacteria to humans, and acts as an important element in the defence against oxidative
  stress and as an enzyme cofactor [[cite:PUB00064727]].