id: Pfam:PF02676
pfam_id: PF02676
name: Methyltransferase TYW3
short_name: TYW3
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02676
counters:
  proteins: 3105
  matches: 3172
  proteomes: 2533
  taxa: 6632
  structures: 6
  alphafold_models: 2640
  domain_architectures: 82
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003827
description: The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast
  to be involved in wybutosine (yW) biosynthesis [[cite:PUB00044611]]. yW is a complexly modified guanosine
  residue that contains a tricyclic base and is found at the 3' position adjacent the anticodon of phenylalanine
  tRNA. TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner [[cite:PUB00044611]].