id: Pfam:PF02677
pfam_id: PF02677
name: Epoxyqueuosine reductase QueH
short_name: QueH
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02677
counters:
  proteins: 2939
  matches: 2957
  proteomes: 2901
  taxa: 5075
  structures: 5
  alphafold_models: 2062
  domain_architectures: 11
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003828
description: The reduction of epoxyqueuosine (oQ) is the last step in the synthesis of the tRNA modification
  queuosine (Q). members of this family were predicted to encode for an alternative epoxyqueuosine reductase.
  Furthermore, it has been suggested that family members are a non-orthologous replacement of queG, responsible
  for oQ to Q conversion. QueH contains conserved cysteines that could be involved in the coordination
  of a Fe/S center in a similar fashion to what has been identified in QueG. No cobalamin was identified
  associated with recombinant QueH protein, indicating that the reduction activity is independent from
  cobalamin [[cite:PUB00085190]].