id: Pfam:PF02678
pfam_id: PF02678
name: Pirin
short_name: Pirin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02678
counters:
  proteins: 36769
  matches: 36808
  proteomes: 15924
  taxa: 24583
  structures: 22
  alphafold_models: 23663
  domain_architectures: 112
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003829
description: This family consists of Pirin proteins from both eukaryotes and prokaryotes. The function
  of Pirin is unknown but the gene coding for this protein is known to be expressed in all tissues in
  the human body although it is expressed most strongly in the liver and heart. Pirin is known to be a
  nuclear protein, exclusively localised within the nucleoplasma and predominantly concentrated within
  dot-like subnuclear structures [[cite:PUB00016051]]. A tomato homologue of human Pirin has been found
  to be induced during programmed cell death [[cite:PUB00020125]]. Human Pirin interacts with Bcl-3 and
  NFI [[cite:PUB00020126]] and hence is probably involved in the regulation of DNA transcription and replication.
  It appears to be an Fe(II)-containing member of the Cupin superfamily.