id: Pfam:PF02679
pfam_id: PF02679
name: (2R)-phospho-3-sulfolactate synthase (ComA)
short_name: ComA
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02679
counters:
  proteins: 2768
  matches: 2796
  proteomes: 2472
  taxa: 4674
  structures: 3
  alphafold_models: 2010
  domain_architectures: 37
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003830
description: In methanobacteria (2R)-phospho-3-sulfolactate synthase (ComA) catalyses the first step of
  the biosynthesis of coenzyme M from phosphoenolpyruvate (P-enolpyruvate). This novel enzyme catalyses
  the stereospecific Michael addition of sulfite to P-enolpyruvate, forming L-2-phospho-3-sulfolactate
  (PSL). It is suggested that the ComA-catalysed reaction is analogous to those reactions catalysed by
  beta-elimination enzymes that proceed through an enolate intermediate [[cite:PUB00010730]].