id: Pfam:PF02698
pfam_id: PF02698
name: DUF218 domain
short_name: DUF218
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02698
counters:
  proteins: 25685
  matches: 25685
  proteomes: 14217
  taxa: 20830
  structures: 1
  alphafold_models: 15881
  domain_architectures: 92
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003848
description: This domain contains several highly conserved charged amino acids, suggesting this may be
  an enzymatic domain (Bateman A pers. obs). The entry includes SanA [swissprot:P33017] and Sfix ([swissprot:O33790])
  from Salmonella typhimurium which are involved in Vancomycin resistance [[cite:PUB00019464]]. These
  proteins may be involved in murein synthesis [[cite:PUB00019465]]. This domain is found in Escherichia
  coli YdcF, which has been shown to bind S-adenosyl-L-methionine (AdoMet), but whose biochemical function
  has not been identified [[cite:PUB00050945]].