id: Pfam:PF02754
pfam_id: PF02754
name: Cysteine-rich domain
short_name: CCG
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02754
counters:
  proteins: 37412
  matches: 67945
  proteomes: 14229
  taxa: 20217
  structures: 19
  alphafold_models: 23792
  domain_architectures: 142
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR004017
description: The key element of this domain is the CX31-38CCX33-34CXXC sequence motif normally found at
  the C-terminus in archaeal and bacterial Hdr-like proteins [[cite:PUB00109129]]. There may be one or
  two copies, and the motif is probably an iron-sulfur binding cluster. In some instances one of the cysteines
  is replaced by an aspartate, and aspartate can in principle also function as a ligand of an iron-sulfur
  cluster [[cite:PUB00109129]]. The entry includes a subunit from heterodisulphide reductase and a subunit
  from glycolate oxidase ([swissprot:P52074]) [[cite:PUB00007282]] and glycerol-3-phosphate dehydrogenase.