id: Pfam:PF02996
pfam_id: PF02996
name: Prefoldin subunit
short_name: Prefoldin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF02996
counters:
  proteins: 12752
  matches: 12782
  proteomes: 4076
  taxa: 10385
  structures: 9
  alphafold_models: 10916
  domain_architectures: 219
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR004127
description: This family comprises of several prefoldin subunits. The biogenesis of the cytoskeletal proteins
  actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric
  protein prefoldin (PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing
  TCP-1). Electron microscopy shows that eukaryotic PFD, which has a similar structure to its archaeal
  counterpart, interacts with unfolded actin along the tips of its projecting arms. In its PFD-bound state,
  actin seems to acquire a conformation similar to that adopted when it is bound to CCT [[cite:PUB00013187]].