id: Pfam:PF03006
pfam_id: PF03006
name: Haemolysin-III related
short_name: HlyIII
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03006
counters:
  proteins: 35375
  matches: 35934
  proteomes: 15659
  taxa: 25660
  structures: 11
  alphafold_models: 27402
  domain_architectures: 242
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR004254
description: Members of this family are integral membrane proteins. This family includes a protein with
  hemolytic activity from Bacillus cereus [[cite:PUB00019707]]. It has been proposed that YOL002c encodes
  a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and
  phosphate metabolism [[cite:PUB00019708]]. In eukaryotes, members are seven-transmembrane pass molecules
  found to encode functional receptors with a broad range of apparent ligand specificities, including
  progestin and adipoQ receptors, and hence have been named PAQR proteins [[cite:PUB00071573]]. The mammalian
  members include progesterone binding proteins [[cite:PUB00071574]]. Unlike the case with GPCR receptor
  proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.
  This family belongs to the CREST superfamily [[cite:PUB00085069]], which are distantly related to GPCRs.