id: Pfam:PF03007
pfam_id: PF03007
name: Wax ester synthase/diacylglycerol acyltransferase catalytic domain
short_name: WS_DGAT_cat
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03007
counters:
  proteins: 15050
  matches: 15215
  proteomes: 4055
  taxa: 6769
  structures: 2
  alphafold_models: 10311
  domain_architectures: 107
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR004255
description: This domain is found in wax ester synthases/diacylglycerol O-acyltransferases (WS/DAGs),
  largely found in bacteria, plants and animals. They catalyse the condensation of a fatty alcohol and
  a fatty acyl-Coenzyme A (acyl-CoA) and they can also catalyse the transesterification of acyl-CoAs with
  diacylglycerols. These are bifunctional enzymes (WS/DAGs) that share low overall sequence similarity
  but all WS/DGATs share a conserved HHXXXDG motif, which is also found in other acyltransferases [[cite:PUB00099698],[cite:PUB00100087]].
  This entry represents the N-terminal catalytic domain of WS/DAGs which contains the conserved HHXXXDG
  motif. It consists of a mixed beta-sheet flanked by four alpha-helices and a small antiparallel beta-sheet
  [[cite:PUB00100087]].