id: Pfam:PF03080
pfam_id: PF03080
name: Neprosin
short_name: Neprosin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03080
counters:
  proteins: 11386
  matches: 11943
  proteomes: 651
  taxa: 1657
  structures: 5
  alphafold_models: 9059
  domain_architectures: 237
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR004314
description: Pitcher plants are insectivorous and secrete a digestive fluid into the pitcher. This fluid
  contains a mixture of enzymes including peptidases. One of these is neprosin, characterized from the
  pitcher plant Nepenthes ventrata. This peptidase is of unknown catalytic type and is unaffected by standard
  peptidase inhibitors. Unusually, activity is directed towards prolyl bonds, but unlike most peptidase
  that cleave after proline, there is no restriction on sequence length or position of the proline residue.
  The peptidase is secreted and is presumed to possess an N-terminal activation peptide. The neprosin
  domain corresponds to the mature peptidase [[cite:PUB00081922]]. It is not known if other proteins with
  this domain are peptidases.