id: Pfam:PF03136
pfam_id: PF03136
name: Pup-ligase protein
short_name: Pup_ligase
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03136
counters:
  proteins: 7051
  matches: 7064
  proteomes: 3457
  taxa: 4287
  structures: 11
  alphafold_models: 4186
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR004347
description: Pupylation is a novel protein modification system found in some bacteria [[cite:PUB00053382]].
  This family of proteins are the enzyme that can conjugate proteins of the Pup family to lysine residues
  in target proteins marking them for degradation. The archetypal protein in this family is PafA (proteasome
  accessory factor) from Mycobacterium tuberculosis [[cite:PUB00053383]]. It has been suggested that these
  proteins are related to gamma-glutamyl-cysteine synthetases [[cite:PUB00053382]].