id: Pfam:PF03159
pfam_id: PF03159
name: XRN 5'-3' exonuclease N-terminus
short_name: XRN_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03159
counters:
  proteins: 10701
  matches: 11038
  proteomes: 3313
  taxa: 8706
  structures: 19
  alphafold_models: 6220
  domain_architectures: 271
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR004859
description: This family aligns residues towards the N-terminus of several proteins with multiple functions.
  The members of this family all appear to possess 5'-3' exonuclease activity [ec:3.1.11.-]. Thus, the
  aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several
  Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation
  and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalysing
  cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing
  of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus [[cite:PUB00020569]].