id: Pfam:PF03266
pfam_id: PF03266
name: NTPase
short_name: NTPase_1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03266
counters:
  proteins: 2847
  matches: 2897
  proteomes: 2218
  taxa: 6361
  structures: 2
  alphafold_models: 2351
  domain_architectures: 41
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR004948
description: This domain is found across all species from bacteria to human, and the function was determined
  first in a hyperthermophilic bacterium to be an NTPase [[cite:PUB00055956]]. The structure of one member-sequence
  represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying
  enzyme [[cite:PUB00032635]]. The sequence carries both a Walker A and Walker B motif which together
  are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human
  liver cholangiocarcinoma when compared to normal tissue [[cite:PUB00041591]].