id: Pfam:PF03353
pfam_id: PF03353
name: Ras-mediated vulval-induction antagonist
short_name: Lin-8
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03353
counters:
  proteins: 166
  matches: 203
  proteomes: 10
  taxa: 26
  structures: 0
  alphafold_models: 164
  domain_architectures: 17
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005020
description: LIN-8 is a nuclear protein, present at the sites of transcriptional repressor complexes,
  which interacts with LIN-35 Rb. Lin35 Rb is a product of the class B synMuv gene lin-35 which silences
  genes required for vulval specification through chromatin modification and remodelling [[cite:PUB00083139]].
  The biological role of the interaction has not yet been determined however predictions have been made.
  The interaction shows that class A synMuv genes control vulval induction through the transcriptional
  regulation of gene expression. LIN-8 normally functions as part of a protein complex however when the
  complex is absent, other family members can partially replace LIN-8 activity [[cite:PUB00083139]].