id: Pfam:PF03357
pfam_id: PF03357
name: Snf7
short_name: Snf7
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03357
counters:
  proteins: 34943
  matches: 35149
  proteomes: 3504
  taxa: 9323
  structures: 31
  alphafold_models: 29923
  domain_architectures: 475
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005024
description: This family of proteins are involved in protein sorting and transport from the endosome to
  the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation
  of both lipids and cellular proteins. In order to perform this degradative function, vacuoles/lysosomes
  contain numerous hydrolases which have been transported in the form of inactive precursors via the biosynthetic
  pathway and are proteolytically activated upon delivery to the vacuole/lysosome. The delivery of transmembrane
  proteins, such as activated cell surface receptors to the lumen of the vacuole/lysosome, either for
  degradation/downregulation, or in the case of hydrolases, for proper localisation, requires the formation
  of multivesicular bodies (MVBs). These late endosomal structures are formed by invaginating and budding
  of the limiting membrane into the lumen of the compartment. During this process, a subset of the endosomal
  membrane proteins is sorted into the forming vesicles. Mature MVBs fuse with the vacuole/lysosome, thereby
  releasing cargo containing vesicles into its hydrolytic lumen for degradation. Endosomal proteins that
  are not sorted into the intralumenal MVB vesicles are either recycled back to the plasma membrane or
  Golgi complex, or remain in the limiting membrane of the MVB and are thereby transported to the limiting
  membrane of the vacuole/lysosome as a consequence of fusion. Therefore, the MVB sorting pathway plays
  a critical role in the decision between recycling and degradation of membrane proteins [[cite:PUB00019523]].
  A few archaeal sequences are also present within this family.