id: Pfam:PF03368
pfam_id: PF03368
name: Dicer dimerisation domain
short_name: Dicer_dimer
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03368
counters:
  proteins: 8259
  matches: 8274
  proteomes: 2973
  taxa: 8119
  structures: 47
  alphafold_models: 1094
  domain_architectures: 386
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005034
description: This domain is found in members of the Dicer protein family which function in RNA interference,
  an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules.
  It is essential for the activity of Dicer [[cite:PUB00067933],[cite:PUB00043694]]. It is a divergent
  double stranded RNA-binding domain [[cite:PUB00043692]]. The N-terminal alpha helix of this domain is
  in a different orientation to that found in canonical dsRNA-binding domains. This results in a change
  of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain
  being in close proximity [[cite:PUB00066744]]. This domain has weak dsRNA-binding activity. It mediates
  heterodimerisation of Dicer proteins with their respective protein partners [[cite:PUB00066744]].