id: Pfam:PF03385
pfam_id: PF03385
name: STELLO glycosyltransferases
short_name: STELLO
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03385
counters:
  proteins: 1545
  matches: 1632
  proteomes: 602
  taxa: 1830
  structures: 0
  alphafold_models: 1297
  domain_architectures: 39
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005049
description: This domain family is found in Metazoa and in Virdiplantae. Two of the family members are
  characterized in Arabidopsis thaliana. [swissprot:O22943] and [swissprot:Q9SCN0] and named STELLO1 (STL1)
  and STELLO2 (STL2) respectively. They are Golgi-localized proteins that can interact with CesAs (cellulose
  synthase A) and control cellulose quantity. In the absence of STELLO function, the spatial distribution
  within the Golgi, secretion and activity of the CSCs are impaired indicating a central role of the STELLO
  proteins in CSC assembly. Point mutations in the predicted catalytic domains of the STELLO proteins
  indicate that they are glycosyltransferases facing the Golgi lumen. STL homologues are present throughout
  the plant kingdom, but STL proteins are distinct from distantly related proteins in nematodes, fungi
  and molluscs [[cite:PUB00081895]].