id: Pfam:PF03401
pfam_id: PF03401
name: Tripartite tricarboxylate transporter family receptor
short_name: TctC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03401
counters:
  proteins: 64590
  matches: 64621
  proteomes: 6826
  taxa: 9512
  structures: 13
  alphafold_models: 38963
  domain_architectures: 60
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005064
description: These probable extra-cytoplasmic solute receptors are strongly overrepresented in several
  beta-proteobacteria [[cite:PUB00019234]]. This family, formerly known as Bug - Bordetella uptake gene
  (bug) product - is a family of bacterial tripartite tricarboxylate receptors of the extracytoplasmic
  solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families
  [[cite:PUB00106922]]. The TctABC system has been characterised in S. typhimurium [[cite:PUB00106923]],
  and TctC is the extracytoplasmic tricarboxylate-binding receptor which binds the transporters TctA and
  TctB, two integral membrane proteins. Complete three-component systems are found only in bacteria [[cite:PUB00106923]].