id: Pfam:PF03478
pfam_id: PF03478
name: KIB1-4 beta-propeller
short_name: Beta-prop_KIB1-4
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03478
counters:
  proteins: 29927
  matches: 32016
  proteomes: 382
  taxa: 1130
  structures: 0
  alphafold_models: 24983
  domain_architectures: 744
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005174
description: This entry represents the beta-propeller domain found in F-box proteins KIB1-4, from Arabidopsis
  thaliana, and similar plant proteins. This domain adopts a beta-propeller structure with 6 blades and
  is often found in association with F-box domain ([pfam:PF00646]). KIB1-4 are ubiquitin ligases that
  act as essential positive regulators in brassinosteroid signalling, mediating the ubiquitination, substrate
  interaction and degradation of GSK3 kinase BIN2 [[cite:PUB00094297]].