id: Pfam:PF03556
pfam_id: PF03556
name: Cullin binding
short_name: Cullin_binding
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03556
counters:
  proteins: 11830
  matches: 11874
  proteomes: 3311
  taxa: 8850
  structures: 30
  alphafold_models: 10278
  domain_architectures: 161
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005176
description: This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for
  neddylation [[cite:PUB00047735],[cite:PUB00050725],[cite:PUB00057468]]. Neddylation is the process by
  which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues
  in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha
  helices [[cite:PUB00047735],[cite:PUB00050725]].