id: Pfam:PF03650
pfam_id: PF03650
name: Mitochondrial pyruvate carriers
short_name: MPC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03650
counters:
  proteins: 9095
  matches: 9202
  proteomes: 3356
  taxa: 8841
  structures: 17
  alphafold_models: 7815
  domain_architectures: 124
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005336
description: This family includes mitochondrial pyruvate carrier proteins, such as Mpc 1/2 and their homologues.
  They mediate the uptake of pyruvate into mitochondria [[cite:PUB00066748]]. In humans, Mpc1 and Mpc2
  associate to form an ~150-kilodalton complex in the inner mitochondrial membrane [[cite:PUB00066748]].
  MPC1 contains two predicted transmembrane regions. MPC2 contains three predicted transmembrane regions.
  Several studies have demonstrated MPC involvement in the control of cell fate in cancer and gluconeogenesis
  in models of type 2 diabetes [[cite:PUB00136144]].