id: Pfam:PF03658
pfam_id: PF03658
name: RnfH family Ubiquitin
short_name: Ub-RnfH
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03658
counters:
  proteins: 4515
  matches: 4515
  proteomes: 4211
  taxa: 5754
  structures: 5
  alphafold_models: 2916
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005346
description: A member of the RnfH family of the ubiquitin superfamily. Members of this family strongly
  co-occur in two distinct gene neighborhood contexts. In one it is associated with a START domain protein,
  a membrane protein SmpA and the transfer mRNA binding protein SmpB. This association suggests a possible
  role in the SmpB-tmRNA-based tagging and degradation system of bacteria, which is interesting given
  that other members of the ubiquitin system are analogously involved in protein-tagging and degradation
  across eukaryotes and various prokaryotes. The second context in which the RnfH genes are present is
  in a membrane associated complex involved in transporting electrons for various reductive reactions
  such as nitrogen fixation [[cite:PUB00034476]].