id: Pfam:PF03661
pfam_id: PF03661
name: Transmembrane protein 33/Nucleoporin POM33
short_name: TMEM33_Pom33
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03661
counters:
  proteins: 4537
  matches: 4581
  proteomes: 3263
  taxa: 8676
  structures: 0
  alphafold_models: 3883
  domain_architectures: 71
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005344
description: This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins.
  Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient
  assembly of nuclear pores [[cite:PUB00075311]]. Proteins in this entry also include Tts1 from fission
  yeasts [[cite:PUB00075313]], Kr-h2 (krueppel homologue 2) from flies [[cite:PUB00075314]] and TMEM33
  from vertebrates [[cite:PUB00085045]]. Tts1 is required for the correct positioning of the cellular
  division plane by delimiting the actomyosin ring assembly at the cell equator [[cite:PUB00075313]].
  Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression [[cite:PUB00075314]].
  TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping
  activity of reticulons [[cite:PUB00085045]].