id: Pfam:PF03669
pfam_id: PF03669
name: PAT complex subunit Asterix
short_name: ASTER
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03669
counters:
  proteins: 2823
  matches: 2834
  proteomes: 2417
  taxa: 6945
  structures: 2
  alphafold_models: 2398
  domain_architectures: 39
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005351
description: This family represents Asterix proteins which are a component of the PAT complex, an endoplasmic
  reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins
  insertion into membranes [[cite:PUB00097218]]. The PAT complex acts as an intramembrane chaperone by
  directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct
  folding, and is needed for optimal biogenesis of multi-pass membrane proteins [[cite:PUB00097218]].
  Asterix is the substrate-interacting subunit of the PAT complex and associates with the first TMD of
  the nascent chain. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within
  the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which TMD1 binds
  [[cite:PUB00097218]].