id: Pfam:PF03671
pfam_id: PF03671
name: Ubiquitin fold modifier 1 protein
short_name: Ufm1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03671
counters:
  proteins: 1961
  matches: 1977
  proteomes: 1382
  taxa: 4552
  structures: 18
  alphafold_models: 1706
  domain_architectures: 36
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005375
description: This is a family of short ubiquitin-like proteins, that is like neither type-1 or type-2.
  It is a ubiquitin-fold modifier 1 (Ufm1) that is synthesised in a precursor form of 85 amino-acid residues.
  In humans the enzyme for Ufm1 is Uba5 and the conjugating enzyme is Ufc1. Prior to activation by Uba5
  the extra two amino acids at the C-terminal region of the human pro-Ufm1 protein are removed to expose
  Gly whose residue is necessary for conjugation to target molecule(s). The mature Ufm1 is conjugated
  to yet unidentified endogenous proteins,[[cite:PUB00034740]]. While Ubiquitin and many Ubls possess
  the conserved C-terminal di-glycine that is adenylated by each specific E1 or E1-like enzyme, respectively,
  in an ATP-dependent manner, Ufm1(1-83) possesses a single glycine at its C-terminus, which is followed
  by a Ser-Cys dipeptide in the precursor form of Ufm1. The C-terminally processed Ufm1(1-83) is specifically
  activated by Uba5, an E1-like enzyme, and then transferred to its cognate Ufc1, an E2-like enzyme [[cite:PUB00034738]].