id: Pfam:PF03690
pfam_id: PF03690
name: Uncharacterised protein family (UPF0160)
short_name: MYG1_exonuc
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03690
counters:
  proteins: 5549
  matches: 5764
  proteomes: 4320
  taxa: 10390
  structures: 21
  alphafold_models: 4529
  domain_architectures: 89
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR003226
description: This entry includes MYG1 exonuclease from human and its orthologues. MYG1 is a 3'-5' exonuclease
  which cleaves in situ on specific transcripts in both nucleus and mitochondrion. It is involved in regulating
  spatially segregated organellar RNA processing, acting as a coordinator of nucleo-mitochondrial crosstalk
  [[cite:PUB00155300]]. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters
  cytoplasmic translation. In mitochondrial matrix, it processes 3'-termini of the mito-ribosomal and
  messenger RNAs and controls translation of mitochondrial proteins [[cite:PUB00155300]]. Overexpression
  of MYG1 has been associated with the autoimmune disorder vitiligo, suggesting that MYG1 may play some
  role in human innate immunity [[cite:PUB00155301]]. Studies in yeast suggested a potential antiviral
  function of MYG1 [[cite:PUB00155302]].