id: Pfam:PF03694
pfam_id: PF03694
name: Erg28 like protein
short_name: Erg28
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03694
counters:
  proteins: 3505
  matches: 3525
  proteomes: 2752
  taxa: 7329
  structures: 0
  alphafold_models: 2990
  domain_architectures: 47
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005352
description: This is a family of integral membrane proteins, which may contain four transmembrane helices.
  Members of this family are thought to be involved in sterol C-4 demethylation. In S. cerevisiae they
  may tether Erg26p (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the endoplasmic
  reticulum or may facilitate interaction between these proteins [[cite:PUB00019518]]. The family contains
  a conserved arginine and histidine that may be functionally important.