id: Pfam:PF03706
pfam_id: PF03706
name: Lysylphosphatidylglycerol synthase TM region
short_name: LPG_synthase_TM
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03706
counters:
  proteins: 23174
  matches: 23283
  proteomes: 12135
  taxa: 17771
  structures: 6
  alphafold_models: 14907
  domain_architectures: 70
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022791
description: LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol
  lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region
  is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic
  antimicrobial molecules - from host immune systems, bacteriocins, defensins, etc - bacteria modify their
  anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of
  the foreign cationic peptides [[cite:PUB00009951],[cite:PUB00109237],[cite:PUB00056129]].