id: Pfam:PF03780
pfam_id: PF03780
name: Asp23 family, cell envelope-related function
short_name: Asp23
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03780
counters:
  proteins: 13917
  matches: 13921
  proteomes: 6035
  taxa: 8426
  structures: 0
  alphafold_models: 8818
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005531
description: The alkaline shock protein Asp23 was identified as an alkaline shock protein that was expressed
  in a sigmaB-dependent manner in Staphylococcus aureus [[cite:PUB00008427]]. Following an alkaline shock
  Asp23 accumulates in the soluble protein fraction of the S. aureus cell. Asp23 is one of the most abundant
  proteins in the cytosolic protein fraction of stationary S. aureus cells, with a copy-number of >25000
  per cell. A second Asp23-family protein, AmaP, which is encoded within the asp23-operon, is required
  to localise Asp23 to the cell membrane [[cite:PUB00075359]]. The overall function for the family is
  thus a cell envelope-related one in Gram-positive bacteria. UniProtKB:Q2FW64 [[cite:PUB00075359]].