id: Pfam:PF03884
pfam_id: PF03884
name: DNA gyrase inhibitor YacG
short_name: YacG
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03884
counters:
  proteins: 6133
  matches: 6133
  proteomes: 6051
  taxa: 8377
  structures: 2
  alphafold_models: 4036
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005584
description: YacG inhibits all the catalytic activities of DNA gyrase by preventing its interaction with
  DNA. It acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding
  by the gyrase [[cite:PUB00060604]]. YacG has been shown to bind zinc and contains the structural motifs
  typical of zinc-binding proteins [[cite:PUB00022116]]. The conserved four cysteine motif in this protein
  (-C-X(2)-C-X(15)-C-X(3)-C-) is not found in other zinc-binding proteins with known structures.