id: Pfam:PF03935
pfam_id: PF03935
name: Beta-glucan synthesis-associated protein SKN1/KRE6/Sbg1
short_name: SKN1_KRE6_Sbg1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03935
counters:
  proteins: 4278
  matches: 5105
  proteomes: 1189
  taxa: 2707
  structures: 0
  alphafold_models: 3577
  domain_architectures: 121
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005629
description: This family consists of the beta-glucan synthesis-associated proteins KRE6, SKN1 and Sbg1.
  Beta1,6-Glucan is a key component of the yeast cell wall, interconnecting cell wall proteins, beta1,3-glucan,
  and chitin. SKN1 and KRE6 show similarities to glycoside hydrolase family 16 glycoside hydrolases, suggesting
  that they are glycosyl hydrolases or transglycosylases. They are related with the synthesis and anchorage
  of cell wall proteins of glucan polymers of the yeast cell wall, although they play redundant roles
  [[cite:PUB00016652],[cite:PUB00095438]]. SKN1, KRE6 and Sbg1 share the SKN1 domain which is conserved
  in SKN1 and KRE6 proteins of many fungal species. Sbg1 is an integral membrane protein essential for
  contractile-ring constriction and septum formation during cytokinesis, which interacts with the conserved
  beta-glucan synthase Bgs1 and regulates its protein levels ans localisation [[cite:PUB00095438],[cite:PUB00095437]].