id: Pfam:PF03966
pfam_id: PF03966
name: Trm112p-like protein
short_name: Trm112p
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03966
counters:
  proteins: 15167
  matches: 15168
  proteomes: 13041
  taxa: 22264
  structures: 41
  alphafold_models: 10889
  domain_architectures: 79
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR005651
description: The function of this family is uncertain. The bacterial members are about 60-70 amino acids
  in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the
  strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes
  with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W [[cite:PUB00020491]].
  The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in
  yeast [[cite:PUB00041889]]. The crystal structure of Ynr046w has been determined to 1.7 A resolution.
  It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain,
  absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices [[cite:PUB00041889]].