id: Pfam:PF03990
pfam_id: PF03990
name: G5-linked-Ubiquitin-like domain
short_name: DUF348
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF03990
counters:
  proteins: 4937
  matches: 12547
  proteomes: 4394
  taxa: 5839
  structures: 1
  alphafold_models: 3055
  domain_architectures: 44
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR007137
description: This domain normally occurs as tandem repeats; however it is found as a single copy in the
  S. cerevisiae DNA-binding nuclear protein YCR593 ([swissprot:P25357]). This protein is involved in sporulation
  part of the SET3C complex, which is required to repress early/middle sporulation genes during meiosis
  ([[cite:PUB00019472]]). The bacterial proteins are likely to be involved in a cell wall function as
  they are found in conjunction with the [pfam:PF07501] domain, which is involved in various cell surface
  processes. This domain is also present in the resuscitation-promoting factors RpfB from Mycobacterium
  tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation
  of dormant cells [[cite:PUB00075582]]. This domain has a beta grasp fold. Structural description of
  this domain revealed a structural conservation between these domains and ubiquitin, hence it is termed
  UBL-G5 [[cite:PUB00137668]].