id: Pfam:PF04002
pfam_id: PF04002
name: RadC-like JAB domain
short_name: RadC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF04002
counters:
  proteins: 19203
  matches: 19208
  proteomes: 13115
  taxa: 19503
  structures: 1
  alphafold_models: 12619
  domain_architectures: 69
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025657
description: A family of proteins present widely across the bacteria. This family was named initially
  with reference to the E. coli radC102 mutation which suggested that RadC was involved in repair of DNA
  lesions [[cite:PUB00009802]]. However the relevant mutation has subsequently been shown to be in recG,
  where radC is in fact an allele of recG [[cite:PUB00044698]]. In addition, a personal communication
  from Claverys, J-P, et al, indicates a total failure of all attempts to characterise a radiation-related
  function for RadC in Streptococcus pneumoniae, suggesting that it is not involved in repair of DNA lesions,
  in recombination during transformation, in gene conversion, nor in mismatch repair. Computational analysis,
  however, provides a possible function. The RadC-like family belong to the JAB superfamily of metalloproteins
  [[cite:PUB00057473]]. The domain shows fusions to an N-terminal Helix-hairpin-Helix (HhH) domain in
  most instances. Other domain combinations include fusions to the anti-restriction module ArdC, the DinG/RAD3-like
  superfamily II helicases and the DNAG-like primase. In some bacteria, closely related DinG/Rad3- like
  superfamily II helicases are fused to a 3'-5' exonuclease in the same position as the RadC-like JAB
  domain. These conserved domain associations lead to the hypothesis that the RadC-like JAB domains might
  function as a nuclease [[cite:PUB00057473]].